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KMID : 0388420000100010017
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Konkuk Journal of Medical Sciences
2000 Volume.10 No. 1 p.17 ~ p.29
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Effects of Ceftezole Sodium on Brunnees Glands of Rats
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Lee Beob-Yi
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Abstract
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This study was performed in male Sprague-Dawley rats to investigate effects of ceftezole sodium(CTZ) on Brunner´s gland. Rats were treated intraperitoneally with CTZ at 1000㎎/㎏/day for 7 consecutive days.
1) Alcian blue (pH 2.5)-P.A.S stain : In Brunner´s gland of the treated group, there was a decrease in red and blue color reactivity. This means that weakly sulfated acid mucin and neutral mucin especially decreased.
2) EM study: In acinus of Brunner´s gland of the treated group, wide and irregular intercellular spaces and small sized secretory vesicles were observed. But any other distinct changes in the cytoplasmic organelles were not detectable.
Consequently, it was suggested that CTZ influences the mucopolysaccharides synthesis in Brunner´s gland.
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KEYWORD
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Brunner´s gland, ceftezole sodium
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